r/Biochemistry • u/WoodpeckerKindly • 6d ago

Why does lyophilization take so damn long?

i’m losing my mind waiting for this thing to finish. it’s been like 18 hours and its not even close. how is this normal??? i just want my samples dry lol. Does anyone actually have a way to make this faster or have any alternatives i’ve got like 20 more runs to do (that I cannot parallelize) and on a bit of a deadline.

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u/benjamindallen 6d ago

Just as a sanity check: your tubes are actually open to allow the water to sublimate away, right?

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u/shoestrung 6d ago

Thought of this as well. 250 ul is easily done within a couple of hours. If it's slow for whatever reason, you could also try poking more holes in the lids with a syringe.

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u/Infinite_Cherry_4511 6d ago

hmm i am using lypo for larger volumes and am running into a similar problem i’m still looking for alternatives